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Article

Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus.

Journal of neuroimmunology - 25 Jun 2009

Perera Devindri, Stankovich Jim, Butzkueven Helmut, Taylor Bruce V, Foote Simon J, Kilpatrick Trevor J, Rubio Justin P

Abstract excerpt

Multiple sclerosis (MS) is a genetically complex autoimmune disease. To dissect further the involvement of four recent identified MS susceptibility genes (KIAA0350, IL2RA, RPL5 and CD58) in disease pathogenesis, we genotyped 94 haplotype-tagging single nucleotide polymorphisms (SNPs) from these loci in 1146 MS cases and 1309 controls. Seven newly-typed SNP variants were nominally associated with risk of MS, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19375175
DOI: 10.1016/j.jneuroim.2009.03.010

Genes

RPL5

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