Article
Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels.
Proceedings of the National Academy of Sciences of the United States of America - 10 Mar 2009
Galli Grazia, Medini Duccio, Borgogni Erica, Zedda Luisanna, Bardelli Monia, Malzone Carmine, Nuti Sandra, Tavarini Simona, Sammicheli Chiara, Hilbert Anne K, Brauer Volker, Banzhoff Angelika, Rappuoli Rino, Del Giudice Giuseppe, Castellino Flora
Abstract excerpt
Immune responses to vaccination are tested in clinical trials. This process usually requires years especially when immune memory and persistence are analyzed. Markers able to quickly predict the immune response would be very useful, particularly when dealing with emerging diseases that require a rapid response, such as avian influenza. To address this question we vaccinated healthy adults at days 1, 22, and 202...
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