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Cutting Edge: Long-Term B Cell Memory in Humans after Smallpox Vaccination

1 Nov 2003

Abstract excerpt

Memory B cells are a central component of humoral immunity, and yet little is known about their longevity in humans. Immune memory after smallpox vaccination (DryVax) is a valuable benchmark for understanding the longevity of B cell memory in the absence of re-exposure to Ag. In this study, we demonstrate that smallpox vaccine-specific memory B cells last for >50 years in immunized individuals. Virus-specific...

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PMID: 14607890
DOI: 10.4049/jimmunol.171.10.4969

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