Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD4 T cell phenotype after AS01-adjuvanted immunization is shaped by prior antigen or pathogen exposure.

Frontiers in immunology - 1 Jan 2026

van der Most Robbert G, Leroux-Roels Geert

Abstract excerpt

CD4 T-cell responses are important for the protection conferred by many infectious disease vaccines and can be quantitatively and qualitatively improved by adjuvants. The AS01 adjuvant is present in critical licensed or candidate vaccines against, amongst others, zoster, respiratory syncytial virus, malaria and tuberculosis. During their clinical development, these vaccines have been evaluated in populations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adjuvants, Immunologic
Share to CD4-Positive T-Lymphocytes
Share to Drug Combinations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunization

Share to Immunologic Memory

Share to Interferon-gamma

Share to Lipid A

Share to Saponins

Source

Open in PubMed Open full text

Identifiers

PMID: 42440506
DOI: 10.3389/fimmu.2026.1800411
PMCID: PMC13333456

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD4 T cell phenotype after AS01-adjuvanted immunization is shaped by prior antigen or pathogen exposure.PMID 42440506Read ↗

Translating innate immunity into immunological memory: implications for vaccine development.Semantic proximity Read ↗

Serial vaccination expands and refines human CD4 <sup>+</sup> T cell memorySemantic proximity Read ↗

Vaccination reshapes the virus-specific T cell repertoire in unexposed adultsSemantic proximity Read ↗

Antigen-specific T cell responses following single and co-administration of tick-borne encephalitis, Japanese encephalitis, and yellow fever virus vaccines: Results from an open-label, non-randomized clinical trial-cohortSemantic proximity Read ↗

Secondary CD8+ T-cell responses are controlled by systemic inflammation.Semantic proximity Read ↗

MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccineSemantic proximity Read ↗

Dynamics of the Cytotoxic T Cell Response to a Model of Acute Viral InfectionSemantic proximity Read ↗

Insights into human CD8(+) T-cell memory using the yellow fever and smallpox vaccines.Semantic proximity Read ↗

Long-lasting stem cell-like memory CD8+ T cells with a naïve-like profile upon yellow fever vaccination.Semantic proximity Read ↗

The Yellow Fever Virus Vaccine Induces a Broad and Polyfunctional Human Memory CD8+ T Cell ResponseSemantic proximity Read ↗

Trained immunity and host‐pathogen interactionsSemantic proximity Read ↗

Develop a durable, memory-driven, CspZ-targeting Lyme disease vaccine by rationale adjuvant selectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.