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Article

A Mouse Model for Laser-induced Choroidal Neovascularization

27 Dec 2015

Abstract excerpt

The mouse laser-induced choroidal neovascularization (CNV) model has been a crucial mainstay model for neovascular age-related macular degeneration (AMD) research. By administering targeted laser injury to the RPE and Bruch's membrane, the procedure induces angiogenesis, modeling the hallmark pathology observed in neovascular AMD. First developed in non-human primates, the laser-induced CNV model has come to be...

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PMID: 26779879
DOI: 10.3791/53502

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