Article
The classical pink-eyed dilution mutation affects angiogenic responsiveness.
PloS one - 1 Jan 2012
Rogers Michael S, Boyartchuk Victor, Rohan Richard M, Birsner Amy E, Dietrich William F, D'Amato Robert J
Abstract excerpt
Angiogenesis is the process by which new blood vessels are formed from existing vessels. Mammalian populations, including humans and mice, harbor genetic variations that alter angiogenesis. Angiogenesis-regulating gene variants can result in increased susceptibility to multiple angiogenesis-dependent diseases in humans. Our efforts to dissect the complexity of the genetic diversity that regulates angiogenesis...
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