Article
Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma.
PLoS genetics - 1 Jan 2018
King Rebecca, Struebing Felix L, Li Ying, Wang Jiaxing, Koch Allison Ashley, Cooke Bailey Jessica N, Gharahkhani Puya, MacGregor Stuart, Allingham R Rand, Hauser Michael A, Wiggs Janey L, Geisert Eldon E
Abstract excerpt
Central corneal thickness (CCT) is one of the most heritable ocular traits and it is also a phenotypic risk factor for primary open angle glaucoma (POAG). The present study uses the BXD Recombinant Inbred (RI) strains to identify novel quantitative trait loci (QTLs) modulating CCT in the mouse with the potential of identifying a molecular link between CCT and risk of developing POAG. The BXD RI strain set was...
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