Article
[Expression of FLT3 internal tandem duplication in pediatric patients with acute myeloid leukemia and its correlation with multidrug resistance].
Zhongguo shi yan xue ye xue za zhi - 1 Feb 2009
Zhao Jiang-Ning, Qiao Zhen-Hua, Xu Lian-Rong, Lu Quan-Yi, Niu Xiao-Qing, Zhang Peng, Wang Zhao
Abstract excerpt
This study was aimed to investigate the expression of FLT3 internal tandem duplication (FLT3-ITD) in pediatric patients with acute myeloid leukemia (AML) and to analyse the clinical features of patients with mutations and the relation of FLT3-ITD with multidrug resistance gene 1 (mdr1). RT-PCR was used to determine the expressions of FIT3-ITD and mdr1 gene in bone marrow samples from 81 new diagnosed pediatric...
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