Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combined therapy of interferon plus ribavirin promotes multiple adaptive solutions in hepatitis C virus.

Journal of medical virology - 1 Apr 2009

Cuevas José M, Torres-Puente Manuela, Jiménez-Hernández Nuria, Bracho María A, García-Robles Inmaculada, Carnicer Fernando, Olmo Juan Del, Ortega Enrique, González-Candelas Fernando, Moya Andrés

Abstract excerpt

Hepatitis C virus (HCV) presents several regions involved potentially in evading antiviral treatment and host immune system. Two regions, known as PKR-BD and V3 domains, have been proposed to be involved in resistance to interferon. Additionally, hypervariable regions in the envelope E2 glycoprotein are also good candidates to participate in evasion from the immune system. In this study, we have used a cohort of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Therapy, Combination
Share to Hepatitis C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-alpha

Share to Interferon alpha-2

Share to Ribavirin

Share to Treatment Failure

Share to Viral Envelope Proteins

Share to Viral Nonstructural Proteins

Source

Identifiers

PMID: 19235859
DOI: 10.1002/jmv.21460

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combined therapy of interferon plus ribavirin promotes multiple adaptive solutions in hepatitis C virus.PMID 19235859Read ↗

Genetic variability of hepatitis C virus before and after combined therapy of interferon plus ribavirin.Semantic proximity Read ↗

On hepatitis C virus evolution: the interaction between virus and host towards treatment outcome.Semantic proximity Read ↗

Understanding the molecular mechanism(s) of hepatitis C virus (HCV) induced interferon resistance.Semantic proximity Read ↗

Genetic diversity of the hepatitis C virus: Impact and issues in the antiviral therapySemantic proximity Read ↗

Intra-host evolutionary dynamics of hepatitis C virus E2 in treated patients.Semantic proximity Read ↗

Hepatitis C virus E2 and NS5A region variability during sequential treatment with two interferon-alpha preparations.Semantic proximity Read ↗

Using evolutionary tools to refine the new hypervariable region 3 within the envelope 2 protein of hepatitis C virus.Semantic proximity Read ↗

Full-length characterization of hepatitis C virus subtype 3a reveals novel hypervariable regions under positive selection during acute infection.Semantic proximity Read ↗

Previous failure of interferon-based therapy does not alter the frequency of HCV NS3 protease or NS5B polymerase inhibitor resistance-associated variants: longitudinal analysis in HCV/HIV co-infected patients.Semantic proximity Read ↗

Viral factors influencing the response to the combination therapy of peginterferon plus ribavirin in chronic hepatitis C.Semantic proximity Read ↗

[Immune evasion mechanisms of hepatitis C virus. Review].Semantic proximity Read ↗

The molecular basis for responsiveness to anti-viral therapy in hepatitis C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.