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Article

Genetic variability of hepatitis C virus before and after combined therapy of interferon plus ribavirin.

PloS one - 26 Aug 2008

Cuevas José Manuel, Torres-Puente Manuela, Jiménez-Hernández Nuria, Bracho María Alma, García-Robles Inmaculada, Wrobel Boris, Carnicer Fernando, del Olmo Juan, Ortega Enrique, Moya Andrés, González-Candelas Fernando

Abstract excerpt

We present an analysis of the selective forces acting on two hepatitis C virus genome regions previously postulated to be involved in the viral response to combined antiviral therapy. One includes the three hypervariable regions in the envelope E2 glycoprotein, and the other encompasses the PKR binding domain and the V3 domain in the NS5A region. We used a cohort of 22 non-responder patients to combined therapy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18725975
DOI: 10.1371/journal.pone.0003058
PMCID: PMC2518109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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