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Genetic diversity of the hepatitis C virus: Impact and issues in the antiviral therapy

1 Jan 2007

Abstract excerpt

The hepatitis C Virus (HCV) presents a high degree of genetic variability which is explained by the combination of a lack of proof reading by the RNA dependant RNA polymerase and a high level of viral replication. The resulting genetic polymorphism defines a classification in clades, genotypes, subtypes, isolates and quasispecies. This diversity is known to reflect the range of responses to Interferon therapy....

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PMID: 17552024
DOI: 10.3748/wjg.v13.i17.2416

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