Article
Using evolutionary tools to refine the new hypervariable region 3 within the envelope 2 protein of hepatitis C virus.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jan 2008
Torres-Puente Manuela, Cuevas José M, Jiménez-Hernández Nuria, Bracho María Alma, García-Robles Inmaculada, Wrobel Borys, Carnicer Fernando, del Olmo Juan, Ortega Enrique, Moya Andrés, González-Candelas Fernando
Abstract excerpt
The envelope 2 protein of hepatitis C virus (HCV) presents three hypervariable regions, named HVR1, HVR2 and HVR3, in which the presence of antigenic sites has been described. Genetic variability in these regions may reflect the generation of escape mutants as a consequence of the immune response. Therefore, these regions would tend to accumulate amino acid changes along the infection process, an effect that...
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