Article

Fitness Landscapes Reveal Simple Strategies for Steering Evolution to Minimize Antibiotic Resistance

2016-12-11

Abstract excerpt

The evolution of antibiotic resistance presents a practical and theoretical challenge: the design of strategies that limit the risk of evolved resistance while effectively treating current patients. Sequentially cycling antibiotics has been proposed as a way to slow the evolution of resistance by reducing the extent of adaptation to a given drug, and clinical trials have demonstrated its effectiveness in some sett...

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Literature Corpus work: 887202ad-53b8-57ce-be75-9688439a5390
DOI: 10.1101/093153

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