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Article

Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization.

Nature cell biology - 1 Mar 2009

Simons Matias, Gault William J, Gotthardt Daniel, Rohatgi Rajeev, Klein Thomas J, Shao Youming, Lee Ho-Jin, Wu Ai-Luen, Fang Yimin, Satlin Lisa M, Dow Julian T, Chen Jie, Zheng Jie, Boutros Michael, Mlodzik Marek

Abstract excerpt

Dishevelled (Dsh) is a cytoplasmic multidomain protein that is required for all known branches of the Wnt signalling pathway. The Frizzled/planar cell polarity (Fz/PCP) signalling branch requires an asymmetric cortical localization of Dsh, but this process remains poorly understood. Using a genome-wide RNA interference (RNAi) screen in Drosophila melanogaster cells, we show that Dsh membrane localization is...

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Identifiers

PMID: 19234454
DOI: 10.1038/ncb1836
PMCID: PMC2803043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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