Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling.

doi:10.1093/emboj/cdg424

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Article

Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling.

The EMBO journal - 1 Sept 2003

Jenny Andreas, Darken Rachel S, Wilson Paul A, Mlodzik Marek

Abstract excerpt

Frizzled (Fz) signaling regulates the establishment of planar cell polarity (PCP). The PCP genes prickle (pk) and strabismus (stbm) are thought to antagonize Fz signaling. We show that they act in the same cell, R4, adjacent to that in which the Fz/PCP pathway is required in the Drosophila eye. We demonstrate that Stbm and Pk interact physically and that Stbm recruits Pk to the cell membrane. Through this...

Topics

Amino Acid Sequence
Animals
Body Patterning
Cell Membrane
Cell Polarity
DNA-Binding Proteins
Drosophila Proteins
Drosophila melanogaster
Epithelial Cells
Eye
Genes, Insect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Vitro Techniques

LIM Domain Proteins

Membrane Proteins

Molecular Sequence Data

Phenotype

Photoreceptor Cells

Sequence Homology, Amino Acid

Source

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Identifiers

PMID: 12941693
DOI: 10.1093/emboj/cdg424
PMCID: PMC202366

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