Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling.

Cell - 3 May 2002

Tree David R P, Shulman Joshua M, Rousset Raphaël, Scott Matthew P, Gubb David, Axelrod Jeffrey D

Abstract excerpt

Planar cell polarity signaling in Drosophila requires the receptor Frizzled and the cytoplasmic proteins Dishevelled and Prickle. From initial, symmetric subcellular distributions in pupal wing cells, Frizzled and Dishevelled become highly enriched at the distal portion of the cell cortex. We describe a Prickle-dependent intercellular feedback loop that generates asymmetric Frizzled and Dishevelled localization....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Polarity
Share to Dishevelled Proteins
Share to Feedback, Physiological

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Frizzled Receptors

Share to LIM Domain Proteins

Share to Osteosarcoma

Share to Wings, Animal

Source

Identifiers

PMID: 12015986
DOI: 10.1016/s0092-8674(02)00715-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling.PMID 12015986Read ↗

Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding.Semantic proximity Read ↗

Planar Cell Polarity Effector Fritz Interacts with Dishevelled and Has Multiple Functions in Regulating PCP.Semantic proximity Read ↗

Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling.Semantic proximity Read ↗

Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing.Semantic proximity Read ↗

Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes.Semantic proximity Read ↗

Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity.Semantic proximity Read ↗

Integrated activity of PDZ protein complexes regulates epithelial polarity.Semantic proximity Read ↗

Planar cell polarity signaling: the developing cell's compass.Semantic proximity Read ↗

Novel regulators of planar cell polarity: a genetic analysis in Drosophila.Semantic proximity Read ↗

Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium.Semantic proximity Read ↗

PDZ proteins and polarity: functions from the fly.Semantic proximity Read ↗

The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.