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Article

Complement component 3 (C3) haplotypes and risk of advanced age-related macular degeneration.

Investigative ophthalmology & visual science - 1 Jul 2009

Park Kyu Hyung, Fridley Brooke L, Ryu Euijung, Tosakulwong Nirubol, Edwards Albert O

Abstract excerpt

PURPOSE: Nonsynonymous coding single nucleotide polymorphisms (nsSNPs) in complement component 3 (C3) alter the risk of age-related macular degeneration (AMD). This was a study of the effect of haplotypes across C3 on AMD risk. METHODS: Nine SNPs tagging haplotypes across C3 were genotyped on 738 subjects at the Mayo Clinic. Haplotype analyses were performed with and without conditioning on individual SNPs....

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Identifiers

PMID: 19234341
DOI: 10.1167/iovs.08-3231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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