Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort.

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Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort.

Molecular vision - 10 Feb 2010

McKay Gareth J, Dasari Shilpa, Patterson Christopher C, Chakravarthy Usha, Silvestri Giuliana

Abstract excerpt

PURPOSE: A non-synonymous single nucleotide polymorphism (SNP) in complement component 3 has been shown to increase the risk of age-related macular degeneration (AMD). We assess its effect on AMD risk in a Northern Irish sample, test for gene-gene and gene-environment interaction, and review a risk prediction model. METHODS: SNP rs2230199 was genotyped in 1,358 samples, which comprised 437 cases, 436 no-disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20157618
PMCID: PMC2820106

Genes

ARMS2
CFB
CFH

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