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Article

Complement component C3 and risk of age-related macular degeneration.

Ophthalmology - 1 Mar 2009

Despriet Dominiek D G, van Duijn Cornelia M, Oostra Ben A, Uitterlinden Andre G, Hofman Albert, Wright Alan F, ten Brink Jacoline B, Bakker Arne, de Jong Paulus T V M, Vingerling Johannes R, Bergen Arthur A B, Klaver Caroline C W

Abstract excerpt

OBJECTIVE: To explore the association between polymorphisms in the complement component 3 (C3) gene and age-related macular degeneration (AMD), and to investigate the modifying effect of complement factor H (CFH) Y402H, LOC387715 A69S and smoking. DESIGN: Pooled data from the prospective, population-based Rotterdam Study (enrolment between 1990 and 1993, and 3 follow-up examinations between September 1, 1993, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19168221
DOI: 10.1016/j.ophtha.2008.09.055

Genes

CFH

Variants

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