Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variation in complement factor 3 is associated with risk of age-related macular degeneration.

Nature genetics - 1 Oct 2007

Maller Julian B, Fagerness Jesen A, Reynolds Robyn C, Neale Benjamin M, Daly Mark J, Seddon Johanna M

Abstract excerpt

The association of variants in complement factors H and B with age-related macular degeneration has led to more intense genetic and functional analysis of the complement pathway. We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related macular degeneration in a large case-control sample.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Complement C3
Share to Complement system in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Macular Degeneration

Share to Retinal Diseases and Treatments

Share to Retinal Imaging and Analysis

Share to Risk Factors

Source

Identifiers

PMID: 17767156
DOI: 10.1038/ng2131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation in complement factor 3 is associated with risk of age-related macular degeneration.PMID 17767156Read ↗

Complement C3 variant and the risk of age-related macular degeneration.Semantic proximity Read ↗

Identification of a rare coding variant in complement 3 associated with age-related macular degeneration.Semantic proximity Read ↗

The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment.Semantic proximity Read ↗

Complement Factor H Variant Increases the Risk of Age-Related Macular DegenerationSemantic proximity Read ↗

Age-related macular degeneration: genetics and biology coming together.Semantic proximity Read ↗

Genetic variants in the complement system predisposing to age-related macular degeneration: a review.Semantic proximity Read ↗

Genetic Insights into Age-Related Macular DegenerationSemantic proximity Read ↗

Age-Related Macular Degeneration: Genetics and Biology.Semantic proximity Read ↗

Complement component C3 and risk of age-related macular degeneration.Semantic proximity Read ↗

Update on the role of genetics in the onset of age-related macular degenerationSemantic proximity Read ↗

Nonsynonymous single nucleotide polymorphisms in the complement component 3 gene are associated with risk of age-related macular degeneration: a meta-analysis.Semantic proximity Read ↗

A genetic approach to stratification of risk for age-related macular degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.