Article
Loss of endothelin-2 in pulmonary neuroendocrine cells promotes the development of hypoxia-induced pulmonary hypertension.
Clinical science (London, England : 1979) - 15 Apr 2026
Suzuki Yoko, Ramadhiani Risa, Ryanto Gusty Rizky Teguh, Musthafa Ahmad, Wardhana Donytra Arby, Morimoto Mitsuru, Ko Chemyong Jay, Nagano Tatsuya, Hara Tetsuya, Yanagisawa Masashi, Emoto Noriaki
Abstract excerpt
Pulmonary hypertension (PH) encompasses a clinical spectrum of diseases with high morbidity and poor survival rates. Over the decades, many studies have reported that endothelin-1 (Edn1) plays a role in several subtypes of PH. However, the beneficial effects of its targeted drugs are only found in patients with group 1 pulmonary arterial hypertension but not in group 3 PH, which is related to lung diseases and...
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