Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature.

Abstract excerpt

Patients with familial pulmonary arterial hypertension inherit heterozygous mutations of the type 2 bone morphogenetic protein (BMP) receptor BMPR2. To explore the cellular mechanisms of this disease, we evaluated the pulmonary vascular responses to chronic hypoxia in mice carrying heterozygous h...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone Morphogenetic Protein Receptors, Type II
• Share to Endothelium, Vascular