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Article

Remodelling of the endothelial extracellular matrix promotes smooth muscle cell hyperplasia in pulmonary hypertension due to left heart disease.

Cardiovascular research - 14 Feb 2026

Nambiar Veetil Netra, Gransar Tara, Liu Shao-Fei, Almalla Ahed, Kirchner Marieluise, Brackin-Helmers Robyn, Hennig Felix, Yeter Ruhi, Weinhart Marie, Mertins Philipp, Falk Volkmar, Szulcek Robert, Kucherenko Mariya M, Kuebler Wolfgang M, Knosalla Christoph

Abstract excerpt

AIMS: Hyperplasia of pulmonary arterial smooth muscle cells (SMCs) contributes to the progression of pulmonary hypertension (PH), yet the underlying pathomechanism of this process in PH secondary to left heart disease (PH-LHD) is poorly understood. We aimed to investigate the role of the endothelial extracellular matrix (ECM), specifically the pulmonary arterial basement membrane (BM), in influencing SMC...

Read the complete abstract on PubMed

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Share to Hyperplasia
Share to Hypertension, Pulmonary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mechanotransduction, Cellular

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Pulmonary Artery

Share to Vascular Remodeling

Share to YAP-Signaling Proteins

Source

Identifiers

PMID: 41334766
DOI: 10.1093/cvr/cvaf238

Genes

YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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