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Article

Discovery of a murine model of clinical PAH: Mission impossible?

Trends in cardiovascular medicine - 1 May 2017

Dai Zhiyu, Zhao You-Yang

Abstract excerpt

Pulmonary arterial hypertension (PAH) is a lung vascular disease characterized with a progressive increase of pulmonary vascular resistance and obliterative pulmonary vascular remodeling resulting in right heart failure and premature death. In this brief review, we document the recent advances in identifying genetically modified murine models of PH, with a focus on the recent discovery of the mouse model of Tie2...

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Share to Antihypertensive Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension, Pulmonary

Share to Hypoxia-Inducible Factor-Proline Dioxygenases

Share to Pulmonary Artery

Share to Receptor, TIE-2

Share to Vascular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 28089339
DOI: 10.1016/j.tcm.2016.12.003
PMCID: PMC5400690

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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