Article
NPR-A-Deficient mice show increased susceptibility to hypoxia-induced pulmonary hypertension.
Circulation - 9 Feb 1999
Zhao L, Long L, Morrell N W, Wilkins M R
Abstract excerpt
BACKGROUND: Mice in which the gene encoding NPR-A, a guanylyl cyclase-linked natriuretic peptide receptor, has been disrupted were used to examine the contribution of natriuretic peptides to maintaining pulmonary vascular homeostasis in normal- and low-oxygen environments. METHODS AND RESULTS: Wi...
Topics
- Analysis of Variance
- Animals
- Chronic Disease
- Genetic Predisposition to Disease
- Genotype
- Guanylate Cyclase
- Hypertension, Pulmonary
- Hypoxia
- In Vitro Techniques
- Mice
- Perfusion
- Receptors, Atrial Natriuretic Factor