Article
NPR-A-Deficient mice show increased susceptibility to hypoxia-induced pulmonary hypertension.
Circulation - 9 Feb 1999
Zhao L, Long L, Morrell N W, Wilkins M R
Abstract excerpt
BACKGROUND: Mice in which the gene encoding NPR-A, a guanylyl cyclase-linked natriuretic peptide receptor, has been disrupted were used to examine the contribution of natriuretic peptides to maintaining pulmonary vascular homeostasis in normal- and low-oxygen environments. METHODS AND RESULTS: Wild-type (+/+), heterozygous (+/-), and homozygous null mutants (-/-) were studied. The response of the pulmonary...
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