Article
NCK Associated Protein 1 Modulated by miRNA-214 Determines Vascular Smooth Muscle Cell Migration, Proliferation, and Neointima Hyperplasia.
Journal of the American Heart Association - 7 Dec 2016
Afzal Tayyab Adeel, Luong Le Anh, Chen Dan, Zhang Cheng, Yang Feng, Chen Qishan, An Weiwei, Wilkes Edmund, Yashiro Kenta, Cutillas Pedro R, Zhang Li, Xiao Qingzhong
Abstract excerpt
BACKGROUND: MicroRNA miR-214 has been implicated in many biological cellular functions, but the impact of miR-214 and its target genes on vascular smooth muscle cell (VSMC) proliferation, migration, and neointima smooth muscle cell hyperplasia is unknown. METHODS AND RESULTS: Expression of miR-214 was closely regulated by different pathogenic stimuli in VSMCs through a transcriptional mechanism and decreased in...
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