Calcium regulation of non-kinase and kinase activities of recombinant myosin light-chain kinase and its mutants.

doi:10.1002/iub.266

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Article

Calcium regulation of non-kinase and kinase activities of recombinant myosin light-chain kinase and its mutants.

IUBMB life - 1 Nov 2009

Xie Ce, Zhang Yue, Wang Hong Hui, Matsumoto Atsushi, Nakamura Akio, Ishikawa Ryoki, Yoshiyama Shinji, Hayakawa Kohichi, Kohama Kazuhiro, Gao Ying

Abstract excerpt

Myosin light-chain kinase (MLCK) comprised of N-terminal actin-binding domain, central catalytic domain, and C-terminal myosin-binding domain. It exerted not only kinase activity to phosphorylate 20 kDa regulatory light chain of smooth muscle but also exerted non-kinase activity on myosin motor and myosin ATPase activities (Nakamura et al., Biochem. Biophys. Res. Commun. 2008, 369, 135). The previous studies on...

Topics

Actins
Binding Sites
Calcium
Calcium-Binding Proteins
Catalytic Domain
Escherichia coli
Mutation
Myosin Light Chains
Myosin-Light-Chain Kinase
Myosins
Protein Structure, Tertiary
Recombinant Proteins

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Open in PubMed

Identifiers

PMID: 19859981
DOI: 10.1002/iub.266

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