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Article

Requirements for transcriptional repression and activation by Engrailed in Drosophila embryos.

Development (Cambridge, England) - 1 Feb 2003

Alexandre Cyrille, Vincent Jean-Paul

Abstract excerpt

Genetic analysis shows that Engrailed (En), a homeodomain-containing transcription factor, has both negative and positive targets. Negative regulation is expected from a factor that has a well-defined repressor domain but activation is harder to comprehend. We used VP16En, a form of En that had its repressor domain replaced by the activation domain of VP16, to show that En activates targets using two parallel...

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Identifiers

PMID: 12506003
DOI: 10.1242/dev.00286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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