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Article

The function of Xenopus germ cell nuclear factor (xGCNF) in morphogenetic movements during neurulation.

Developmental biology - 15 May 2003

Barreto Guillermo, Reintsch Wolfgang, Kaufmann Christine, Dreyer Christine

Abstract excerpt

The germ cell nuclear factor (GCNF, NR6A1) is a nuclear orphan receptor first described in the mouse testis and subsequently identified as an essential transcription factor in vertebrate embryogenesis. Here, we analyze the phenotype of Xenopus embryos after depletion of embryonic GCNF (xEmGCNF) protein using a specific morpholino antisense oligonucleotide. Morphological defects after xEmGCNF knockdown became...

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PMID: 12729562
DOI: 10.1016/s0012-1606(03)00109-x

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