Article
Nk6, a novel Drosophila homeobox gene regulated by vnd.
Mechanisms of development - 1 Aug 2002
Uhler Jay, Garbern James, Yang Li, Kamholz John, Mellerick Dervla M
Abstract excerpt
Nk(x)-type homeobox genes are an evolutionarily conserved family that regulate diverse developmental processes. Here we describe a novel Drosophila gene, Nk6, which encodes an Nk-type transcription factor most homologous to vertebrate Nkx6.1 and Nkx6.2. The homeodomains and NK decapeptide domains of all three proteins are highly conserved. Nk6 is expressed in the embryonic brain, ventral nerve cord, hindgut, and...
Topics
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Base Sequence
- Basic Helix-Loop-Helix Transcription Factors
- Central Nervous System
- DNA, Complementary
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Evolution, Molecular
- Gene Expression Regulation, Developmental
- Genes, Homeobox