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Article

Generation of a Novel Nkx6-1 Venus Fusion Reporter Mouse Line.

International journal of molecular sciences - 26 Mar 2021

Burtscher Ingo, Tarquis-Medina Marta, Salinno Ciro, Schirge Silvia, Beckenbauer Julia, Bakhti Mostafa, Lickert Heiko

Abstract excerpt

Nkx6-1 is a member of the Nkx family of homeodomain transcription factors (TFs) that regulates motor neuron development, neuron specification and pancreatic endocrine and β-cell differentiation. To facilitate the isolation and tracking of Nkx6-1-expressing cells, we have generated a novel Nkx6-1 Venus fusion (Nkx6-1-VF) reporter allele. The Nkx6-1-VF knock-in reporter is regulated by endogenous cis-regulatory...

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Identifiers

PMID: 33810480
DOI: 10.3390/ijms22073434
PMCID: PMC8036392

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