Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling.

doi:10.1038/19315

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Article

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling.

Nature - 15 Apr 1999

Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell T M, Rubenstein J L, Ericson J

Abstract excerpt

During vertebrate development, the specification of distinct cell types is thought to be controlled by inductive signals acting at different concentration thresholds. The degree of receptor activation in response to these signals is a known determinant of cell fate, but the later steps at which g...

Topics

Animals
Body Patterning
Cell Lineage
Culture Techniques
DNA-Binding Proteins
Embryonic Induction
Eye Proteins
Genes, Homeobox
Hedgehog Proteins
Homeobox Protein Nkx-2.2
Homeodomain Proteins
Interneurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Motor Neurons

Mutation

Neurons

PAX6 Transcription Factor

Paired Box Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 10217145
DOI: 10.1038/19315

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-10217145-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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