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Article

Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009

Lee Kyu Pil, Yuan Joseph P, Zeng Weizhong, So Insuk, Worley Paul F, Muallem Shmuel

Abstract excerpt

Ca(2+) influx by store-operated Ca(2+) influx channels (SOCs) mediates many cellular functions regulated by Ca(2+), and excessive SOC-mediated Ca(2+) influx is cytotoxic and associated with disease. One form of SOC is the CRAC current that is mediated by Orai channels activated by STIM1. A fundamental property of the native CRAC and of the Orais is fast Ca(2+)-dependent inactivation, which limits Ca(2+) influx to...

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Source

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Identifiers

PMID: 19706554
DOI: 10.1073/pnas.0904664106
PMCID: PMC2732841

Genes

STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels.PMID 19706554Read ↗

A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.Semantic proximity Read ↗

Review: Structure and Activation Mechanisms of CRAC Channels.Semantic proximity Read ↗

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels.Semantic proximity Read ↗

Ca2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel.Semantic proximity Read ↗

Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.Semantic proximity Read ↗

Gated regulation of CRAC channel ion selectivity by STIM1.Semantic proximity Read ↗

The inactivation domain of STIM1 is functionally coupled with the Orai1 pore to enable Ca2+-dependent inactivation.Semantic proximity Read ↗

A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels.Semantic proximity Read ↗

Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1.Semantic proximity Read ↗

Orai1 is an essential pore subunit of the CRAC channel.Semantic proximity Read ↗

SOAR and the polybasic STIM1 domains gate and regulate Orai channels.Semantic proximity Read ↗

Sequential Steps of CRAC Channel Activation.Semantic proximity Read ↗

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