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Article

Genotype determination for polymorphisms in linkage disequilibrium.

BMC bioinformatics - 20 Feb 2009

Yu Zhaoxia, Garner Chad, Ziogas Argyrios, Anton-Culver Hoda, Schaid Daniel J

Abstract excerpt

BACKGROUND: Genome-wide association studies with single nucleotide polymorphisms (SNPs) show great promise to identify genetic determinants of complex human traits. In current analyses, genotype calling and imputation of missing genotypes are usually considered as two separated tasks. The genotypes of SNPs are first determined one at a time from allele signal intensities. Then the missing genotypes, i.e.,...

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PMID: 19228433
DOI: 10.1186/1471-2105-10-63
PMCID: PMC2753842

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