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Article

Efficiency and power as a function of sequence coverage, SNP array density, and imputation.

PLoS computational biology - 1 Jan 2012

Flannick Jason, Korn Joshua M, Fontanillas Pierre, Grant George B, Banks Eric, Depristo Mark A, Altshuler David

Abstract excerpt

High coverage whole genome sequencing provides near complete information about genetic variation. However, other technologies can be more efficient in some settings by (a) reducing redundant coverage within samples and (b) exploiting patterns of genetic variation across samples. To characterize as many samples as possible, many genetic studies therefore employ lower coverage sequencing or SNP array genotyping...

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PMID: 22807667
DOI: 10.1371/journal.pcbi.1002604
PMCID: PMC3395607

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