Article
Genotype imputation in genome-wide association studies.
Current protocols in human genetics - 1 Jul 2013
Porcu Eleonora, Sanna Serena, Fuchsberger Christian, Fritsche Lars G
Abstract excerpt
Imputation is an in silico method that can increase the power of association studies by inferring missing genotypes, harmonizing data sets for meta-analyses, and increasing the overall number of markers available for association testing. This unit provides an introductory overview of the imputation method and describes a two-step imputation approach that consists of the phasing of the study genotypes and the...
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