Article
Fast accurate missing SNP genotype local imputation.
BMC research notes - 3 Aug 2012
Wang Yining, Cai Zhipeng, Stothard Paul, Moore Steve, Goebel Randy, Wang Lusheng, Lin Guohui
Abstract excerpt
BACKGROUND: Single nucleotide polymorphism (SNP) genotyping assays normally give rise to certain percents of no-calls; the problem becomes severe when the target organisms, such as cattle, do not have a high resolution genomic sequence. Missing SNP genotypes, when related to target traits, would confound downstream data analyses such as genome-wide association studies (GWAS). Existing methods for recovering the...
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