Article
Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro susceptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America.
BMC microbiology - 19 Feb 2009
Dalla Costa Elis R, Ribeiro Marta O, Silva Márcia S N, Arnold Liane S, Rostirolla Diana C, Cafrune Patricia I, Espinoza Roger C, Palaci Moises, Telles Maria A, Ritacco Viviana, Suffys Philip N, Lopes Maria L, Campelo Creuza L, Miranda Silvana S, Kremer Kristin, da Silva Pedro E Almeida, Fonseca Leila de Souza, Ho John L, Kritski Afrânio L, Rossetti Maria L R
Abstract excerpt
BACKGROUND: Mutations associated with resistance to rifampin or streptomycin have been reported for W/Beijing and Latin American Mediterranean (LAM) strain families of Mycobacterium tuberculosis. A few studies with limited sample sizes have separately evaluated mutations in katG, ahpC and inhA genes that are associated with isoniazid (INH) resistance. Increasing prevalence of INH resistance, especially in high...
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