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Article

GWAS-identified multiple sclerosis risk loci involved in immune response: validation in Russians.

Journal of neuroimmunology - 15 May 2015

Bashinskaya V V, Kulakova O G, Kiselev I S, Baulina N M, Favorov A V, Boyko A N, Tsareva E Yu, Favorova O O

Abstract excerpt

Multiple sclerosis (MS) is a chronic neuro-inflammatory disease of complex etiology. The results of GWAS, a high-throughput method to discover genetic architecture of MS, require replication in independent ethnic groups. We performed a replication study of nine GWAS-identified SNPs in immune response in Russians. Associations of CLEC16A and IL2RA with MS were validated. Besides, we observed the associations of...

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PMID: 25903733
DOI: 10.1016/j.jneuroim.2015.03.015

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