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Article

Atherosclerosis proceeds independently of thrombin-induced platelet activation in ApoE-/- mice.

Atherosclerosis - 1 Aug 2009

Hamilton J R, Cornelissen I, Mountford J K, Coughlin S R

Abstract excerpt

Platelet activation has long been postulated to contribute to the development of atherosclerotic plaques, although the mechanism by which this might occur remains unknown. Thrombin is a potent platelet activator and transfusion of thrombin-activated platelets into mice increases plaque formation, suggesting that thrombin-induced platelet activation might contribute to platelet-dependent atherosclerosis. Platelets...

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Share to Apolipoproteins E
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19217621
DOI: 10.1016/j.atherosclerosis.2009.01.018
PMCID: PMC2717183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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