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Article

Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis.

Blood - 18 Nov 2010

Lievens Dirk, Zernecke Alma, Seijkens Tom, Soehnlein Oliver, Beckers Linda, Munnix Imke C A, Wijnands Erwin, Goossens Pieter, van Kruchten Roger, Thevissen Larissa, Boon Louis, Flavell Richard A, Noelle Randolph J, Gerdes Norbert, Biessen Erik A, Daemen Mat J A P, Heemskerk Johan W M, Weber Christian, Lutgens Esther

Abstract excerpt

CD40 ligand (CD40L), identified as a costimulatory molecule expressed on T cells, is also expressed and functional on platelets. We investigated the thrombotic and inflammatory contributions of platelet CD40L in atherosclerosis. Although CD40L-deficient (Cd40l(-/-)) platelets exhibited impaired p...

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Source

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Identifiers

PMID: 20705757
DOI: 10.1182/blood-2010-01-261206
PMCID: PMC2993630

Genes

CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20705757-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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