Article
Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E-deficient mice is independent of genetic alterations in plasminogen activator inhibitor-1.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2000
Sjöland H, Eitzman D T, Gordon D, Westrick R, Nabel E G, Ginsburg D
Abstract excerpt
Impaired fibrinolysis has been linked to atherosclerosis in a number of experimental and clinical studies. Plasminogen activator inhibitor type 1 (PAI-1) is the primary inhibitor of plasminogen activation and has been proposed to promote atherosclerosis by facilitating fibrin deposition within developing lesions. We examined the contribution of PAI-1 to disease progression in 2 established mouse models of...
Topics
- Animals
- Apolipoproteins E
- Arteriosclerosis
- Endothelium, Vascular
- Fibrin
- Fibrinolysis
- Genotype
- Male
- Mice
- Mice, Knockout
- Plasminogen Activator Inhibitor 1
- Receptors, LDL
- Tunica Intima