Article
In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa.
The Journal of infectious diseases - 1 Mar 2009
Sisowath Christin, Petersen Ines, Veiga M Isabel, Mårtensson Andreas, Premji Zul, Björkman Anders, Fidock David A, Gil José P
Abstract excerpt
BACKGROUND: Artemether-lumefantrine (AL) is a major and highly effective artemisinin-based combination therapy that is becoming increasingly important as a new first-line therapy against Plasmodium falciparum malaria. However, recrudescences occurring after AL treatment have been reported. Identification of drug-specific parasite determinants that contribute to treatment failures will provide important tools for...
Topics
- Alleles
- Animals
- Antimalarials
- Artemether, Lumefantrine Drug Combination
- Artemisinins
- Child
- Chloroquine
- Drug Combinations
- Drug Resistance
- Ethanolamines