Article
The role of Pfmdr1 and Pfcrt in changing chloroquine, amodiaquine, mefloquine and lumefantrine susceptibility in western-Kenya P. falciparum samples during 2008-2011.
PloS one - 1 Jan 2013
Eyase Fredrick L, Akala Hoseah M, Ingasia Luiser, Cheruiyot Agnes, Omondi Angela, Okudo Charles, Juma Dennis, Yeda Redemptah, Andagalu Ben, Wanja Elizabeth, Kamau Edwin, Schnabel David, Bulimo Wallace, Waters Norman C, Walsh Douglas S, Johnson Jacob D
Abstract excerpt
Single Nucleotide Polymorphisms (SNPs) in the Pfmdr1, and Pfcrt, genes of Plasmodium falciparum may confer resistance to a number of anti-malaria drugs. Pfmdr1 86Y and haplotypes at Pfcrt 72-76 have been linked to chloroquine (CQ) as well as amodiaquine (AQ) resistance. mefloquine (MQ) and lumefantrine (LU) sensitivities are linked to Pfmdr1 86Y. Additionally, Pfcrt K76 allele carrying parasites have shown...
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