Article
Sustained Ex Vivo Susceptibility of Plasmodium falciparum to Artemisinin Derivatives but Increasing Tolerance to Artemisinin Combination Therapy Partner Quinolines in The Gambia.
Antimicrobial agents and chemotherapy - 1 Dec 2017
Amambua-Ngwa Alfred, Okebe Joseph, Mbye Haddijatou, Ceesay Sukai, El-Fatouri Fatima, Joof Fatou, Nyang Haddy, Janha Ramatoulie, Affara Muna, Ahmad Abdullahi, Kolly Olimatou, Nwakanma Davis, D'Alessandro Umberto
Abstract excerpt
Antimalarial interventions have yielded a significant decline in malaria prevalence in The Gambia, where artemether-lumefantrine (AL) has been used as a first-line antimalarial for a decade. Clinical Plasmodium falciparum isolates collected from 2012 to 2015 were analyzed ex vivo for antimalarial susceptibility and genotyped for drug resistance markers (pfcrt K76T, pfmdr1 codons 86, 184, and 1246, and pfk13) and...
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