Article
Trends in chloroquine resistance marker, Pfcrt-K76T mutation ten years after chloroquine withdrawal in Tanzania.
Malaria journal - 14 Nov 2013
Mohammed Asia, Ndaro Arnold, Kalinga Akili, Manjurano Alphaxard, Mosha Jackline F, Mosha Dominick F, van Zwetselaar Marco, Koenderink Jan B, Mosha Frank W, Alifrangis Michael, Reyburn Hugh, Roper Cally, Kavishe Reginald A
Abstract excerpt
BACKGROUND: Plasmodium falciparum resistance to anti-malarial drugs remains a major obstacle to the control of malaria. In 2001 Tanzania replaced chloroquine (CQ) with sulphadoxine-pyrimethamine (SP) as first-line drug, which in turn was replaced by artemisinin combination therapy in 2006. SP has however, continued to be used in intermittent preventive treatment of malaria in pregnancy (IPTp) despite reports of...
Topics
- Adolescent
- Adult
- Aged
- Antimalarials
- Child
- Child, Preschool
- Chloroquine
- DNA, Protozoan
- Drug Resistance
- Female
- Genotype