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Evolutionary Insights from Association Rule Mining of Co-Occurring Mutations in Influenza Hemagglutinin and Neuraminidase.

Viruses - 25 Sept 2024

Galeone Valentina, Lee Carol, Monaghan Michael T, Bauer Denis C, Wilson Laurence O W

Abstract excerpt

Seasonal influenza viruses continuously evolve via antigenic drift. This leads to recurring epidemics, globally significant mortality rates, and the need for annually updated vaccines. Co-occurring mutations in hemagglutinin (HA) and neuraminidase (NA) are suggested to have synergistic interactions where mutations can increase the chances of immune escape and viral fitness. Association rule mining was used to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosylation

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Influenza A Virus, H3N2 Subtype

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Source

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Identifiers

PMID: 39459850
DOI: 10.3390/v16101515
PMCID: PMC11512220

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