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Article

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

21 Nov 2008

Abstract excerpt

Efforts to model pancreatic cancer in mice have focused on mimicking genetic changes found in the human disease, particularly the activating KRAS mutations that occur in pancreatic tumors and their putative precursors, pancreatic intraepithelial neoplasia (PanIN). Although activated mouse Kras mutations induce PanIN lesions similar to those of human, only a small minority of cells that express mutant Kras go on...

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PMID: 19028876
DOI: 10.1073/pnas.0810111105

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