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Article

Genetic alterations associated with progression from pancreatic intraepithelial neoplasia to invasive pancreatic tumor.

Gastroenterology - 1 Nov 2013

Murphy Stephen J, Hart Steven N, Lima Joema Felipe, Kipp Benjamin R, Klebig Mitchell, Winters Jennifer L, Szabo Csilla, Zhang Lizhi, Eckloff Bruce W, Petersen Gloria M, Scherer Steven E, Gibbs Richard A, McWilliams Robert R, Vasmatzis George, Couch Fergus J

Abstract excerpt

BACKGROUND & AIMS: Increasing grade of pancreatic intraepithelial neoplasia (PanIN) has been associated with progression to pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms that control progression from PanINs to PDAC are not well understood. We investigated the genetic alterations involved in this process. METHODS: Genomic DNA samples from laser-capture microdissected PDACs and adjacent PanIN2...

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Identifiers

PMID: 23912084
DOI: 10.1053/j.gastro.2013.07.049
PMCID: PMC3926442

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KRAS

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