Article
Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia.
The American journal of pathology - 1 Jul 2007
Zhu Liqin, Shi Guanglu, Schmidt C Max, Hruban Ralph H, Konieczny Stephen F
Abstract excerpt
A number of studies have shown that pancreatic ductal adenocarcinoma develops through precursor lesions termed pancreatic intraepithelial neoplasia (PanIN). PanINs are thought to initiate in the small ducts of the pancreas through activating mutations in the KRAS proto-oncogene. What remains unanswered is the identification of the individual cell type(s) that contributes to pancreatic ductal adenocarcinoma...
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